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生存率:在COVID-19感染中的一个关键的亡抑制剂及其对治疗方案的影响
1Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Saudi journal of biological sciences
|June 4, 2024
概括
在COVID-19患者中,白细胞亡和扩散的增加. 预防这种亡的策略可能有助于减轻严重的COVID-19结果和淋巴缺血症.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 冠状病毒疾病 (COVID-19) 对细胞亡和增殖的影响尚未得到充分了解.
- 病毒可以操纵宿主细胞的过程,如亡和增殖,以影响感染结果.
- 了解这些细胞变化对于理解COVID-19病原体至关重要.
研究的目的:
- 为了评估COVID-19患者的周围血液细胞中的亡和增殖率.
- 为了比较疫苗接种前和接种后的患者与健康对照的这些比率.
- 探索特定免疫标记在COVID-19相关细胞变化的作用.
主要方法:
- 从新确诊的COVID-19患者和健康对照组中分析周围血液细胞 (淋巴细胞和粒细胞).
- 对亡和扩散水平的评估.
- 测量可溶性Fas连接物 (FaSL) 和介素-38 (IL-38) 的水平.
主要成果:
- 与对照人群相比,在COVID-19患者的淋巴细胞和粒细胞中观察到大量的增殖和亡.
- 在COVID-19患者中检测到可溶性Fas连接体 (FaSL) 和IL-38的升高水平.
- 接种疫苗或从COVID-19中恢复过来的个人显示出更高的生存率,表明潜在的肺损伤减轻.
结论:
- 白血细胞 (WBC) 亡在COVID-19病原和病原性中起着至关重要的作用.
- 免疫调节失调,由高的FaSL和IL-38表明,与COVID-19有关.
- 准WBC亡是一种潜在的治疗策略,可以预防淋巴缺血和严重的COVID-19结果.
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