基于纤维素和糖的口服分散薄膜转化了难溶的黄素的固态和溶解特征
Helmy Yusuf1, Orchidea Meidy Nurintan Savitri1, Nadia Natsya Al-Khalifi1
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, Indonesia.
概括
开发口服分散薄膜 (ODTF) 增强了黄素 (CUR) 的溶解性和溶解性. 基于纤维素的ODTF显示出优越的物理性能,与原始CUR相比,改善了CUR溶解的3.2倍.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 黄素 (CUR) 是一种植物性药物,是生物制药分类系统 (BCS) 第四类化合物,具有较差的水溶性和组织透性.
- 有效的配方策略对于克服CUR在治疗应用中的物理化学限制至关重要.
研究的目的:
- 开发和优化口服分散薄膜 (ODTF) 以提高黄素 (CUR) 输送.
- 研究ODTF作为固体分散矩阵的潜力,以改善CUR溶解性和透性.
主要方法:
- 使用溶剂造技术,使用基于纤维素 (HPMC,CMC) 和基于糖 (MDX) 的聚合物制备ODTF.
- 波洛克萨默 (POL) 被用作表面活性剂和溶解剂,以帮助药物分散和薄膜可湿性.
- 电影的特点是形态学,药物结晶性 (XRD),相混合性 (DSC),溶解率和溶解效率.
主要成果:
- 开发的ODTF表现出光滑,平坦的表面,均的CUR分散,由XRD和DSC证实.
- ODTFs阻止了CUR再结晶,这是由于POL和聚合物矩阵的溶解效应.
- 与原始CUR相比,ODTF显示CUR溶解的3.2倍增加.
- 基于纤维素的薄膜比基于糖的薄膜具有更有利的物理性能.
结论:
- 口服分散的薄膜有效地为黄素 (CUR) 创建了一个固体分散矩阵.
- ODTF配方显著提高了CUR的溶解率和效率,克服了其不良溶解性.
- 基于纤维素的ODTF是一种有前途的平台,可以改善CUR等难溶性药物的口服输送.
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