纯血动物在第一次长期训练期间体内血小板激活的生物标志物
Arianna Miglio1, Emanuela Falcinelli2, Anna Maria Mezzasoma2
1Department of Veterinary Medicine, Perugia University, Perugia, Italy.
Frontiers in veterinary science
|June 4, 2024
概括
血小板激活标志物,可溶性P-选择素和血小板衍生的细胞外囊泡,在早期训练期间表明纯血动物的过度活跃. 这些标记可能有助于监测马匹运动员.
科学领域:
- 马的运动生理学
- 血小板生物学 血小板生物学
- 运动期间的血液静止.
背景情况:
- 体育炼对训练有素和未训练有素的人的影响不同.
- 可溶性P-选择素 (sP-sel) 和血小板衍生的细胞外囊泡 (PEVs) 是人类体内血小板激活的已知标志物.
- 人类的训练适应导致这些标记物的休息水平下降,这是由于血液动力学适应能力的改善.
研究的目的:
- 评估可溶性P-选择素和PEVs作为体内血小板功能的标志物在接受初始训练的纯血动物中.
- 评估从未训练过的马在增量训练的前四个月期间这些标记的变化.
主要方法:
- 29名未经训练的纯血犬接受了90天的增量训练计划.
- 在基线 (T0),30天 (T30) 和90天 (T90) 收集血液样本进行分析.
- 进行了血小板计数,sP-sel (ELISA) 和PEVs (流细胞计) 的量化.
主要成果:
- 溶性P-选择因水平在T30显示上升趋势,到T90.0恢复到基线.
- 与基线相比,循环PEVs (CD61+/AnnV+) 在T30和T90显著升高,表明持续的血小板过活.
- 这些发现表明,在最初的训练期间,血小板活化增加.
结论:
- 循环sP-sel和PEV是研究运动诱导的马体运动员血静变化的有希望的工具.
- 这些标记可以为运动适应提供宝贵的见解,并帮助赛马选择运动.
- 这项研究强调了这些标记物在马训练期间监测血小板功能的有用性.
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