手足口病:EPs® 7630可以作为一种治疗选择吗? 一项前性随机开放式多中心临床研究
Murat Sütçü1,2, Manolya Kara3, Funda Yıldız2
1Pediatric Infectious Diseases, Faculty of Medicine, Istinye University, Istanbul, Türkiye.
Frontiers in pediatrics
|June 4, 2024
概括
在患有手足口病 (HFMD) 的儿童中,EPs® 7630显著降低了症状持续时间和住院率. 这种草药治疗证明了有利的安全性,为HFMD管理提供了潜在的新选择.
科学领域:
- 儿童传染病 儿童传染病
- 草药研究 草药研究
- 临床药理学 临床药理学
背景情况:
- 手足口病 (HFMD) 是儿童常见的病毒性疾病,目前尚无特定的抗病毒治疗方法.
- 人类肠道病毒 (EVs) 和 Coxsackievirus (CVs) 是HFMD的主要致病原体.
- 在之前的研究中,EPs® 7630是一种草药制剂,已显示出抗感染和免疫调节作用.
研究的目的:
- 调查EPs® 7630作为诊断为HFMD的儿童治疗的疗效和安全性.
- 评估EPs® 7630对儿科HFMD患者疾病持续时间,症状严重程度和住院率的影响.
主要方法:
- 一项前性,随机的多中心临床研究,涉及208名患有HFMD的儿童.
- 参与者在症状出现后48小时内被录取,并分配到EPs® 7630或对照组.
- 后续评估发生在48小时,5-7天,并通过电话进行持续投诉.
主要成果:
- 与对照组 (8.58天) 相比,EPs® 7630组的疾病持续时间明显较短 (6.07天) (p < 0.001).
- 在48小时和5-7天后,EPs® 7630组的投诉得分明显较低 (p < 0.001).
- 在EPs® 7630组中,住院率显著降低 (p = 0.019),仅报告了轻微的副作用.
结论:
- EPs® 7630在减少儿童HFMD的持续时间和严重程度方面表现出显著的有效性.
- 这种草药表现出良好的安全性,并注明了最小的不良影响.
- EPs® 7630为治疗儿科HFMD提供了一个有希望的,可行的草本治疗方案.
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