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肠道微生物组的变化伴随着在ROHHAD综合征下腹部手术后的代谢正常化
Alessandra Granato1, Paul M Ryan2, Anthony Wong1
1Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 1H3, Canada.
JCEM case reports
|June 4, 2024
概括
鲁克斯-en-Y胃绕道成功治疗了一个患有低通风,下丘脑和自主失调 (ROHHAD) 综合征的快速发病肥胖症的儿童. 这项手术改善了肥胖,自主功能障碍和肠道微生物组,提供了新的治疗途径.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 胃肠病学 胃肠病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 快速发作的肥胖与低通风,下丘脑和自主失调 (ROHHAD) 综合征呈现出快速体重增加和自主功能障碍.
- 目前的管理主要集中在症状控制上,因为缺乏疾病修饰疗法.
研究的目的:
- 报道第一个成功的干预ROHHAD综合征使用减肥手术.
- 为了评估Roux-en-Y胃绕道对ROHHAD的儿科患者肥胖,dysautonomia和代谢障碍的影响.
主要方法:
- 一份病例报告详细介绍了一名患有ROHHAD综合征的儿科患者,他接受了Roux-en-Y胃旁路术.
- 在手术后48个月内对人体测量,代谢概况和便微生物组合的纵向评估.
主要成果:
- 显著降低BMI (9.5kg/m2) 和改善代谢状态,包括胰岛素断奶,改善HbA1c,脂质和肝酶.
- 手术后慢性腹的解决,在显著减肥之前.
- 减肥手术后肠道微生物组合,生物量和分类学多样性的明显变化.
结论:
- 腹腔外科手术,特别是Roux-en-Y胃绕道,在治疗ROHHAD综合征方面显示出潜在的有效性.
- 该程序可以导致代谢健康的长期改善以及肠道微生物组合和生物质的显著改变.
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