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相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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C4 Pathway and CAM01:27

C4 Pathway and CAM

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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相关实验视频

Updated: Jun 24, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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DiscoverPath:一个知识提炼和检索系统,用于跨学科的生物医学研究.

Yu-Neng Chuang1, Guanchu Wang1, Chia-Yuan Chang2

  • 1Rice University.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management
|June 4, 2024
PubMed
概括

DiscoverPath是一款用于生物医学研究的新型知识图 (KG) 搜索引擎. 它通过使用命名实体识别 (NER) 和部分语音 (POS) 标签来可视化研究连接来增强文章的发现.

关键词:
生物医学 生物医学医疗保健 医疗保健 医疗保健 医疗保健信息检索系统信息检索系统知识图表知识图表推者系统推者系统

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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相关实验视频

Last Updated: Jun 24, 2025

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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科学领域:

  • 生物医学研究生物医学研究
  • 信息科学 信息科学 信息科学
  • 计算机科学 计算机科学

背景情况:

  • 学术出版物呈指数级增长,使得有效的检索变得困难.
  • 传统的搜索引擎在跨学科研究和各种术语方面扎.
  • 需要先进的工具来帮助研究人员发现相关的文章.

研究的目的:

  • 为了介绍DiscoverPath,一个基于生物医学研究的知识图表搜索引擎.
  • 为了提高用户在发现相关查询和文章的体验.
  • 促进跨学科的知识探索.

主要方法:

  • 使用命名实体识别 (NER) 和部分语音 (POS) 标记来从摘要中提取术语和关系.
  • 从提取的信息构建了一个知识图 (KG).
  • 开发了一个专注的子图可视化和一个查询推系统.
  • 集成了一个可访问的图形用户界面 (GUI),以实现直观的交互.

主要成果:

  • DiscoverPath有效地提取术语和关系来构建一个KG.
  • 该系统通过呈现聚焦的子图来减少信息过载.
  • 查询建议使搜索查询的代改进成为可能.
  • 图形界面提供了直观的可视化和详细的文章信息.

结论:

  • DiscoverPath通过基于KG的搜索增强了生物医学研究文章的检索能力.
  • 该系统通过改进查询和文章发现来促进跨学科的知识探索.
  • DiscoverPath为浏览复杂的科学文献提供了一个易于访问和高效的解决方案.