解读癌症二十年的细胞重编程:对不断变化的趋势和研究前沿进行文献分析
Jinghao Liang1, Yijian Lin2, Yuanqing Liu2
1Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Heliyon
|June 4, 2024
概括
细胞重编程为癌症进展和复发提供了新的见解,超越了传统的线性模型. 图书统计分析揭示了这一不断发展的瘤学领域的关键趋势和有影响力的研究.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 图书统计学 图书统计学
背景情况:
- 癌症研究正在从线性进展模型转向包括细胞重编程.
- 遗传和表观遗传因素,包括Wnt和Notch通路,驱动癌细胞状态的变化.
- 表皮介质转变 (EMT) 和治疗诱导的压力对癌症复发有显著的贡献.
研究的目的:
- 从2002年到2022年进行细胞重编程在瘤学中的文献分析.
- 确定癌症细胞重编程的关键趋势,有影响力的研究和新兴领域.
- 为改善癌症治疗策略提供见解.
主要方法:
- 在科学网络数据库 (2002-2022) 中进行文献搜索.
- 使用Citespace,VOSviewer和Bibliometrix进行图书统计分析.
- 分析了3102篇文章,重点关注关键词,引用引用和出版趋势.
主要成果:
- 美国和中国是主要的贡献者,德克萨斯大学MD安德森癌症中心作为一个关键机构.
- 门内德斯被认为是最有影响力的学者;癌症杂志发表了最多的文章.
- "癌症的标志:下一代"是被引用最多的文件.
- 最近的研究重点是细胞外囊泡,癌症治疗和细胞可塑性.
结论:
- 图书统计分析强调了细胞重编程在瘤学中的日益重要.
- 该领域充满活力,新兴的研究领域为新的癌症治疗提供了潜力.
- 这种分析有助于专家们理解和推进癌症细胞重编程研究.
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