血清基丁因与慢性病 (CKD) 有关:基于NHANESES的横截面研究
Meng'en Zhu1, Zhimin Bi2, Yaoling Wang1
1Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Renal failure
|June 4, 2024
概括
吸烟代谢物氧丁的水平升高与慢性病 (CKD) 的风险增加有关. 这一发现表明,氧丁可以作为CKD发展的潜在生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 吸烟是慢性病 (CKD) 的已知危险因素之一.
- 尼古丁的主要代谢物氧丁在CKD发展中的特定作用尚不清楚.
- 对于针对戒烟和脏保护的公共卫生倡议来说,了解基丁和CKD之间的关联至关重要.
研究的目的:
- 为了研究血清中氧科提宁水平与慢性病 (CKD) 的患病率之间的潜在关系.
- 确定氧科丁因是否可以作为CKD的生物标志物.
- 探索氧科丁因与估计的膜过率 (eGFR) 之间的相关性.
主要方法:
- 分析了来自NHANES 2017 - 2020年3月20岁及以上的8,544名参与者的数据.
- 根据eGFR < 60 mL/(min*1.73 m2) 定义的CKD.
- 使用ID HPLC-APCI MS/MS测量的血清氧丁;与皮尔森系数和多变量逻辑回归分析的相关性.
主要成果:
- 在非CKD和CKD组中,血清基丁与eGFR呈负相关性.
- 在调整为混因子后,血清基氨酸≥0.015 ng/mL的参与者患CKD的几率明显更高 (OR = 1.505,p < 0.001).
- 在血清中氧科提宁水平和CKD患病率之间观察到积极的关联.
结论:
- 血清基丁可以与慢性病 (CKD) 有积极的关联.
- 氧丁因显示出作为评估CKD风险的生物标志物的潜力.
- 需要进行进一步的研究,以确定CKD评估的最佳氧丁度值.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
84
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
84
01:10Nephrons
2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
109
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
109
01:11Renal Failure: Dose Adjustments
84
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
84