大自然的载体:利用细胞外囊泡进行向药物输送
Qi Chen1, Yuyi Zheng2, Xuhong Jiang3
1Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, P. R. China.
Drug delivery
|June 4, 2024
概括
细胞外囊泡 (EVs) 与针对性药物输送 (TDD) 的传统方法相比,具有优势. 本综述探讨了TDD的可扩展的EV生产,加载,准和临床应用.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 细胞外囊泡 (EVs) 越来越多地被认为是它们在先进的药物输送系统中的潜力.
- 与传统方法相比,EVs为向药物递送 (TDD) 提供了更好的向,生物相容性,稳定性和障碍透性.
研究的目的:
- 审查电动汽车的批量生产,重点关注可扩展,成本效益和可重复的方法.
- 讨论电动汽车装载技术,主动准策略及其在TDD中的应用.
- 为解决基于EV的TDD的安全性,监管考虑和临床翻译前景.
主要方法:
- 文献综述侧重于细胞外囊泡的产生和向药物递送应用.
- 对扩大电动汽车制造规模的挑战和战略的分析.
- 检查电动汽车负载,准机制以及安全/监管方面的问题.
主要成果:
- 电动汽车对TDD具有显著的优势,包括固有的准和生物相互作用能力.
- 可扩展和可重复生产电动汽车仍然是一个关键挑战,正在探索各种战略.
- 积极准和高效的加载方法对于优化基于EV的TDD有效性至关重要.
结论:
- 电动汽车对于彻底改变向药物输送具有巨大的前景,但生产和临床翻译方面的挑战仍然存在.
- 严格的研究和标准化的协议对于推进基于电动汽车的疗法至关重要.
- 解决安全性,监管障碍和证明临床疗效对于成功将电动汽车转化为治疗剂至关重要.
相关概念视频
Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis
1.0K
Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
1.0K
COP Coated Vesicles
7.8K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
7.8K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
513
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
513
Cellular Membranes and Drug Transport
433
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
433
Overview of Secretory Vesicles
8.5K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.5K


