主体气管和肠道微生物组在体外抑制菌体的生长
Susana Tejeda-Garibay1,2, Lihong Zhao3,4, Nicholas R Hum2
1Quantitative and Systems Biology, Graduate Program, University of California, Merced, Merced, California, USA.
Microbiology spectrum
|June 4, 2024
概括
宿主微生物群,包括乳酸菌和葡萄球菌,可以在体外抑制Coccidioides真菌的生长. 抗生素的使用可能会破坏这种防御,可能会恶化山谷热的结果.
科学领域:
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
背景情况:
- 菌菌 (山谷热) 是一种真菌感染,经常被误诊为细菌性肺炎,导致过度使用抗生素.
- 抗生素治疗可能会导致微生物组失生症,对真菌疾病的结果有未知的影响.
- 主体微生物群在控制Coccidioides真菌感染中的作用在很大程度上尚未被探索.
研究的目的:
- 研究气管和肠道微生物组在体外抑制Coccidioides生长的潜力.
- 为了确定抗生素诱导的微生物群枯竭是否会影响Coccidioides抑制.
- 在宿主微生物群中识别可能抑制Coccidioides的细菌物种.
主要方法:
- 在体外共同培养试验中,使用Coccidioides和宿主微生物群在各种介质上进行测定.
- 抗生素盘扩散试验用于评估部分微生物群枯竭的影响.
- 16S rRNA测序用于识别气管,肠道和肺样本中的细菌种群.
主要成果:
- 在GYE和哥伦比亚血上生长的宿主微生物群抑制了Coccidioides的生长,与巧克力不同.
- 通过抗生素盘对微生物群的部分消耗减少了Coccidioides的抑制.
- 16S rRNA 测序确定了 Lactobacillus 和 Staphylococcus 作为潜在负责真菌抑制的关键细菌属.
结论:
- 与宿主相关的细菌,特别是乳酸菌和葡萄球菌,在体外具有对菌的抑制活性.
- 通过抗生素破坏宿主微生物群,可能会损害对Coccidioides的自然防御.
- 保持微生物群的完整性可能对有效清除真菌和防止Coccidioides进展至关重要.
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