非原核和单原核衍生的胚芽细胞不会损害随后的产周和产妇结局
Qiuyu Xu1, Xiaoyan Mao1, Jie Zhang1
1Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
The Journal of clinical endocrinology and metabolism
|June 4, 2024
概括
从非原核 (0PN) 和单核 (1PN) 胚胎转移芽细胞是安全的. 与两个前核 (2PN) 胚胎相比,这些胚胎没有影响生殖结果,也没有增加孕产妇和产周并发症.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 围产期结局的结果
背景情况:
- 临床实践优先考虑来自两个前核 (2PN) 胚胎的囊胞.
- 关于从非原核 (0PN) 和单原核 (1PN) 胚胎转移胚芽细胞的存在争论.
研究的目的:
- 为了研究来自0PN和1PN胞胎的玻璃化加热单胞胎的围产和产科结局.
主要方法:
- 从2012年到2021年进行的回顾性队列研究,包括7284名女性.
- 对比了0PN和1PN胚胎细胞移植与2PN胚胎细胞移植的结果.
- 分析了临床怀孕,流产,活产,产妇并发症和分娩方式.
主要成果:
- 临床怀孕,流产和活产率在0PN,1PN和2PN胚胎组中是相似的.
- 在0PN和2PN组之间没有观察到出生结果,孕产妇并发症或分娩方式的显著差异.
- 1PN组的结果与2PN相似,男性出生率明显增加.
结论:
- 转移0PN和1PN芽细胞不会影响生殖结果.
- 没有增加的孕产妇或产周并发症与0PN和1PN芽细胞移植有关.
- 这些发现支持受试管婴儿治疗的夫妇做出明智的决策.
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