口服THC急性作用中的性别差异:一个随机的,安慰剂控制的,交叉的人类实验室研究
Ardavan Mohammad Aghaei1, Lia Urban Spillane1, Brian Pittman1
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Psychopharmacology
|June 4, 2024
概括
与男性相比,女性在口服THC (dronabinol) 后报告了更强烈的主观"高",尽管有类似的生理和心理效应. 这突显了大麻精神活性反应中的潜在性别差异,为未来的大麻使用障碍 (CUD) 研究提供了信息.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 越来越多的女性使用大麻,引发了人们对大麻使用障碍 (CUD) 的担忧.
- 临床前数据表明,性别影响大麻素效应,但人类数据有限.
- 这项研究解决了对口服四大麻素 (THC) 急性反应的性别差异理解的差距.
研究的目的:
- 调查健康成年人口服THC急性影响的性别差异.
- 检查生物性别如何影响对THC的主观,心理模拟,认知和生理反应.
主要方法:
- 一项随机的,安慰剂控制的研究,涉及56名健康的男性和女性,先前接触过大麻,但没有CUD.
- 参与者接受了一次10毫克口服THC (dronabinol) 的剂量.
- 评估了主观影响 (例如",高"),心理模拟症状,口头学习 (RAVLT) 和心率.
主要成果:
- 口服THC产生了与剂量相关的心理模拟和生理效应,但没有影响RAVLT结果.
- 对主观"高"分数观察到显著的性别THC相互作用,女性报告的强度更大 (p=0.05).
- 在心理模拟,认知或生理测量方面没有发现其他显著的性别特异性相互作用.
结论:
- 急性口服THC给药导致男性和女性的心理模拟和生理效应相似.
- 女性可能会从口服THC中体验到更明显的主观精神活性效应.
- 需要进一步的研究来确定漏洞,并为CUD.开发定制的干预措施.
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