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多功能聚合物纳米纤维支架富含亚齐尔沙坦美多克索米尔,可增强伤口愈合

Alka¹, Nidhi Mishra¹, Priya Singh^1,2

¹Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University Lucknow (A Central University), Uttar Pradesh, Vidya Vihar, Raebareli Road, Lucknow, 226025, Uttar Pradesh, India.

Drug delivery and translational research

|June 4, 2024

概括

这项研究开发了以阿齐尔沙坦美多克索米尔丰富的纳米纤维支架 (AZL-CS/PVA-NF) 以提高伤口愈合. 这些支架表现出强大的抗菌活性,并在体内加速组织再生.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

长时间的伤口愈合是一个重大的临床挑战.
纳米技术为伤口护理提供了创新的解决方案.
多功能纳米纤维支架可以改善药物输送和组织修复.

研究的目的:

开发和表征阿齐尔沙坦美多克索米尔 (AZL) 富含奇托/聚乙烯醇 (CS/PVA) 的纳米纤维支架 (AZL-CS/PVA-NF) 用于伤口愈合.
评估AZL-CS/PVA-NF在促进伤口修复方面的体外和体内疗效.
评估开发的支架的抗微生物和抗炎性质.

主要方法:

电是用来制造AZL-CS/PVA-NF的.
脚手架的物理特性 (直径,抗拉强度) 和药物释放动力学的特征.
在体外进行了针对金黄色葡萄球菌和空气菌的抗微生物测试.
在Wistar大鼠的体内研究包括评估组织再生标记物 (Akt,CD31,Stat3) 和炎症性细胞因子 (IL-6,IL-1β,TNF-α).

主要成果:

AZL-CS/PVA-NF 的平均直径为 240.42 ± 3.55 nm,拉伸强度为 18.05 ± 1.18 MPa.
观察到高的药物释放率 (93.86±2.04%在pH7.4的48小时内).
证明了对测试细菌的显著抗微生物疗效.
增加的Akt和CD31水平,减少的Stat3和减少的炎症标志物表明加强了组织再生和修复.

结论:

开发的AZL-CS/PVA-NF支架显示出卓越的伤口愈合活性.
这些支架具有强大的抗微生物和抗炎作用.
AZL-CS/PVA-NF作为新型药物载体和先进伤口护理应用的包裹具有前景.

关键词:

药物输送是药物输送的过程.电纳米纤维脚手架的电.模仿细胞外基质的细胞外基质专题专题专题专题伤口愈合伤口愈合

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