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代谢性减肥手术后妊娠糖尿病风险和低出生体重:一个复杂的相互作用要平衡
Diana Rodrigues-Martins1,2,3, Sara Andrade2,3, Sofia S Pereira2,3
1Centro Materno-Infantil do Norte - Centro Hospitalar Universitário de Santo António (CMIN-CHUdSA), Porto, Portugal.
Obesity surgery
|June 4, 2024
概括
代谢性减肥手术 (MBS) 在肥胖女性中显著减少妊娠糖尿病 (GD). 然而,这种益处可能与后代的出生体重较低有关,强调需要仔细考虑风险和益处.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 腹部外科 腹部外科
背景情况:
- 代谢性减肥手术 (MBS) 被认为可以改善产科结果,并预防肥胖女性的妊娠糖尿病 (GD).
- 在没有引入额外风险的情况下,MBS减少GD的程度仍然是对母亲和婴儿健康的关键关注点.
研究的目的:
- 评估代谢性减肥手术 (MBS) 对妊娠糖尿病 (GD) 患病率和其他怀孕结果的影响.
- 为了比较经过MBS的妇女与匹配的非手术对照者的怀孕结果.
主要方法:
- 采用了追溯病例控制研究设计.
- 79名先前接受MBS的妇女的怀孕结果与79名年龄和怀孕前BMI匹配的非手术对照进行了比较.
主要成果:
- 孕期糖尿病 (GD) 在MBS组的发生率明显低 (7.6%与19%,p=0.03).
- 在MBS后的第一和第二个季度观察到更低的禁食血糖水平.
- 虽然怀孕年龄较小 (SGA) 在MBS后更频繁,但在控制吸烟习惯后,这种差异并不显著. 在孕期体重增加,早产或分娩方式方面没有发现显著差异.
结论:
- 代谢性减肥手术 (MBS) 与妊娠糖尿病 (GD) 的患病率较低,与与妊娠前BMI相似的未经手术的女性相比.
- 在MBS后GD的减少可能与较低的出生体重有关,这表明在怀孕期间对葡萄糖代谢的影响与体重无关.
- 这些发现强调了需要平衡MBS对母体葡萄糖调节的益处与对胎儿生长的潜在影响.
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