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Updated: Jun 15, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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使用头到尾环酶来制备混合RiPPs

Tung Le1, Dongtianyu Zhang1, Rachel M Martini2

  • 1Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. vddonk@illinois.edu.

Chemical communications (Cambridge, England)
|June 4, 2024
PubMed
概括

研究人员通过结合cyclotide和lanthipeptide生物合成途径创造了新的混合循环. 这项工作展示了工程具有增强的稳定性和活性的新可能性.

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Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...