在产前饥荒暴露后60年加速的生物衰老
Mengling Cheng1,2, Dalton Conley3, Tom Kuipers4
1Swiss Centre of Expertise in Life Course Research, Faculty of Social and Political Sciences, University of Lausanne, Lausanne CH 1015, Switzerland.
概括
早期的饥荒暴露,一种逆境形式,与幸存者的加速生物衰老有关. 这项研究使用表观遗传钟来测量荷兰饥饿冬季家庭研究参与者的衰老,发现衰老速度更快,特别是在女性中.
科学领域:
- 表观遗传学和衰老研究.
- 健康和疾病的发育起源.
- 营养流行病学 营养流行病学
背景情况:
- 假设早期的逆境加速了生物衰老.
- 荷兰饥饿冬季家庭研究 (DHWFS) 提供了一个独特的自然实验来调查这一假设.
- 表观遗传钟提供了生物年龄的分子测量.
研究的目的:
- 为了确定是否在子宫内暴露于饥荒会加速生物衰老.
- 评估饥荒暴露对特定表观遗传衰老时钟 (DunedinPACE,GrimAge,PhenoAge) 的影响.
- 检查饥荒对衰老的影响中的性别差异和妊娠时间.
主要方法:
- 从DHWFS参与者的血液样本中分析DNA甲基化数据 (N=951).
- 使用DunedinPACE,GrimAge和PhenoAge表观遗传钟量化生物衰老.
- 在饥荒幸存者和匹配的对照者之间比较表观遗传年龄加速.
主要成果:
- 与对照组相比,饥荒幸存者表现出明显更快的DunedinPACE分数,女性观察到的效果更强.
- GrimAge还表明幸存者的衰老加速,尽管效果大小较小.
- 两组之间没有检测到PhenoAge的显著差异.
- 饥荒对衰老的影响独立于血液细胞组成和妊娠时间.
结论:
- 在荷兰饥饿冬季的子宫内营养不良似乎加速了晚年生物衰老.
- 像DunedinPACE和GrimAge这样的表观遗传衰老时钟对生命早期的环境侮辱很敏感.
- 这些发现凸显了早期生活逆境对健康轨迹的长期影响.
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