多变量基因架构揭示了当代人类的丸激素驱动的性敌意
Anasuya Chakrabarty1, Saikat Chakraborty1,2, Diptarup Nandi1,3
1Biotechnology Research Innovation Council-National Institute of Biomedical Genomics, Kalyani 741251, West Bengal, India.
概括
人类遗传学的性别差异很常见,但共同的遗传架构可以限制进化变化. 激素驱动性对抗,影响特征进化和生殖成功.
科学领域:
- 人类遗传学 人类遗传学
- 进化生物学是进化的生物学.
- 生殖健康 生殖健康
背景情况:
- 性差异 (SD) 在人类中很普遍,但两性之间潜在的共同遗传结构 (SGA) 是复杂的.
- 分析单个特征的单一变量方法不足以理解SD,因为特征相互依赖和遗传相关性.
研究的目的:
- 研究人类特征的多变量遗传结构中的性别差异.
- 探索性对抗 (SA) 和在塑造SD中的作用.
- 评估SGA对SD施加的进化约束.
主要方法:
- 利用多变量方法估计12个人体测量,脂肪沉积和性激素表型的附加遗传 (共变) 差.
- 分析了跨性别跨特征的共变性,以确定SA.
- 采用多变量进化模拟来建模SGA,SA和SD进化之间的相互作用.
主要成果:
- 在跨性别跨特征共变中发现了显著的性对抗性 (SA),特别是在和人类特征之间.
- 观察到,这些共差的27%具有相反的标志,导致SGA中的不对称性.
- 发现SGA主要在性对抗性选择下限制SD进化.
- 终身生殖成功显示了与人体特征的积极遗传相关性,但不是.
- 证明了两性多变异性特征组合的遗传变异的枯竭,表明了进化约束.
结论:
- 丸激素是当代人类性对抗的关键驱动力.
- 多变量框架对于全面了解基因架构中的性别差异至关重要.
- 遗传约束对人类性别差异和特征组合的演变产生重大影响.
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