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Updated: Jun 24, 2025

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

545

通过小分子模拟来激活VCP的Allosteric激活,一个AAA解酶,小分子模拟

Natalie H Jones1,2, Qiwen Liu1, Linas Urnavicius1

  • 1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065.

Proceedings of the National Academy of Sciences of the United States of America
|June 4, 2024
PubMed
概括

研究人员发现了一种新型的激活剂,VAA1,用于AAA酶氨酸含蛋白 (VCP). 这种小分子准了全位,为VCP调节提供了一个新的机制,以及针对相关疾病的潜在治疗策略.

关键词:
这是一种AAA蛋白质.激活器激活器是什么低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.机械酶是一种机械酶.小分子分子小分子

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