复合 Cu(II) 复合物,通过向细胞氧化还原稳定性,协同增强细胞毒性和抗瘤免疫反应

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Updated: Jun 24, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

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Ke-Bin Huang1, Feng-Yang Wang1, Yuan Lu1

  • 1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.

Proceedings of the National Academy of Sciences of the United States of America
|June 4, 2024
PubMed
概括

研究人员开发了一种新的基于金属的复合物Cu-1,通过破坏氧化还原稳定来选择性向癌细胞. 这种方法诱导免疫细胞死亡 (ICD) 并抑制瘤生长,副作用最小.

关键词:
破坏了氧化还原恒温.铁性化 (ferroptosis) 是一种免疫性细胞死亡 免疫性细胞死亡金属复杂复杂的金属.

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