在注意力缺陷多动症疾病的动物模型中,酒精戒断和安非他胺的联合使用
Pooja M Shah1, Nicholas R Pillarella1, Marta Telatin1
1Department of Biology, Monmouth University, West Long Branch, NJ, USA.
The American journal of drug and alcohol abuse
|June 4, 2024
概括
患有ADHD类症状的青少年大鼠显示酒精戒断严重程度降低,即使同时使用安非他命. 这表明该模型中对酒精使用问题的意识下降,突出了潜在的风险.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 非医学性兴奋剂的使用,特别是与酒精一起使用,是注意力缺陷/多动障碍 (ADHD) 治疗中的一个问题.
- 以前的研究表明,安非他胺可以减少青少年大鼠的酒精戒断症状.
研究的目的:
- 为了研究乙醇-安非他胺联合使用对青少年自发高血压大鼠 (SHR) 戒酒的影响,ADHD模型.
- 为了比较SHR中的戒断症状与Long-Evans (LE) 和Wistar京都 (WKY) 控制大鼠.
主要方法:
- 青少年大鼠 (SHR,WKY,LE) 通过液体饮食获得乙醇和/或安非他胺,长达26天.
- 在治疗后,老鼠接受了戒断,并评估了戒断的严重程度,运动活动和类似焦虑的行为.
主要成果:
- 与LE和WKY大鼠相比,SHR的整体酒精戒断严重程度较低.
- 氨基胺的同时使用减少了LE和WKY大鼠的戒断严重程度,但不是SHR.
- 只有WKY大鼠在戒断期间表现出增加的焦虑,这种焦虑通过同时服用安非他胺来缓解.
结论:
- 青少年SHR,模拟ADHD,表现出对显著的酒精戒断症状的抵抗力.
- 虽然安非他胺可以减轻一些老鼠菌株的酒精戒断,但SHR没有显示出这种效果,可能掩盖了酒精使用问题.
- 对戒酒意识的降低可能会导致ADHD患者未被发现的有问题的酒精使用.
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