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Updated: Jun 24, 2025

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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在神经药物开发中绕过或覆盖第二阶段试验的患病率和影响

Hannah Moyer1, Robyn Mellett1, Karine Vigneault1

  • 1From the Department of Equity, Ethics and Policy (H.M., R.M., K.V., M.M., J. Kimmelman), McGill University, Montreal, Quebec, Canada; Penn Memory Center (J. Karlawish), University of Pennsylvania, Philadelphia; Clinical Trials Unit (E.A.), Kennedy Krieger Institute, Baltimore, MD; Departments of Psychiatry and Behavioral Sciences and Neurology, Keck School of Medicine (L.S.), and L. Davis School of Gerontology (L.S.), University of Southern California, Los Angeles.

Neurology
|June 4, 2024
PubMed
概括

近一半的神经药物第三阶段试验没有积极的第二阶段疗效数据. 这种被称为第二阶段绕过或重写的做法与危害增加无关,但需要合理性的标准.

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