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炎症性关节炎患者吸收肺炎球菌疫苗:单一中心队列研究
Deepak Nagra1, Katie Bechman1, Mark D Russell1
1Centre for Rheumatic Disease, King's College London, London, UK.
Rheumatology (Oxford, England)
|June 4, 2024
概括
肺炎球菌疫苗的接种率在患有炎症性类风湿性疾病的患者中较低,特别是年轻人和未接受生物疗法的患者. 需要有针对性的策略来提高这一脆弱人群的疫苗接种率.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 目前的指导方针建议65岁以上或免疫抑制的个人接种肺炎球菌疫苗.
- 炎症性类风湿性疾病 (IRD) 可能会增加对肺炎球菌感染的易感性.
- 疫苗接种在不同患者群体和不同类型的疫苗中存在差异.
研究的目的:
- 评估炎症性关节炎患者的肺炎球菌,流感和COVID-19疫苗接种情况.
- 为了确定影响这一群体接种疫苗的因素.
- 将肺炎球菌疫苗接种量与其他常规疫苗接种量进行比较.
主要方法:
- 英国的一项回顾性单中心队列研究.
- 包括患有类风湿性关节炎,牛皮性关节炎和轴性脊柱关节炎的患者.
- 后勤回归分析以确定疫苗接种的预测因素,调整人口统计和临床因素.
主要成果:
- 肺炎球菌疫苗接种率为35%,明显低于流感 (63%) 和COVID-19 (87%) 疫苗.
- 高龄 (≥65岁) 和生物疗法与较高的肺炎球菌疫苗接种率有关.
- 坚持疫苗接种和免疫联合委员会 (JCVI) 的指标也预测了疫苗接种的增加.
结论:
- 在患有炎症性类风湿性疾病的患者中,肺炎球菌疫苗的摄入量仍然低于最佳水平.
- 较年轻的患者和未接受生物治疗的患者代表了针对性疫苗接种工作的关键群体.
- 需要一个独特的战略来提高肺炎球菌疫苗接种覆盖率在这个人口.
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