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Updated: Jun 24, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

依赖BATF的Th17细胞通过IL-23R通路起作用,促进前列腺腺癌的开始和进展

Sen Liu¹, Seleste L Rivero¹, Bing Zhang^1,2

¹Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA, USA.

Journal of the National Cancer Institute

|June 4, 2024

概括

转录因子BATF对于Th17细胞分化和前列腺癌的发展至关重要. 针对BATF-IL-23R轴可能提供新的前列腺癌治疗策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

在前列腺癌中T辅助17 (Th17) 细胞的作用尚不清楚.
转录因子BATF对于Th17细胞的分化至关重要.
缺乏BATF的小鼠缺乏Th17细胞,影响免疫反应.

研究的目的:

研究BATF依赖的Th17细胞在前列腺癌中的功能.
阐明BATF影响前列腺瘤发展的机制.
为了探索前列腺癌中的IL-23-IL-23R信号通路.

主要方法:

交叉繁殖BATF淘汰赛小鼠与Pten条件突变小鼠.
在基因改造小鼠中分析前列腺形态,瘤发育和细胞过程.
评估IL-23-IL-23R信号传递和炎症细胞透.
评估抗IL-23p19抗体治疗对前列腺瘤的影响.
在人类前列腺瘤中与IL-23A和IL-23R相关的BATFmRNA水平.

主要成果:

在Pten突变小鼠中,BATF缺乏减少了前列腺大小,腺癌发育,增殖和血管生成.
在BATF淘汰赛小鼠中,IL-23-IL-23R信号传递和炎症细胞透率降低.
反IL-23p19治疗降低了前列腺瘤和Pten缺乏小鼠的血管生成.
人类前列腺瘤显示了BATF和IL-23/IL-23R表达之间的正相关性.

结论:

通过IL-23-IL-23R信号传递,BATF依赖的Th17细胞促进前列腺癌的开始和进展.
BATF-IL-23R轴代表了前列腺癌的潜在治疗标.
针对这一轴可能会导致新的前列腺癌预防和治疗策略.

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