流体p16和SATB2表达不能区分非典型多腺瘤 (APA) 与其良性模仿者
Chau Minh Bui1, Mahzad Azimpouran, Bonnie Balzer
1Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California.
概括
p16和SATB2免疫组织化学可以帮助区分非典型的多腺瘤 (APA) 与肌肉侵入性子宫内膜腺癌. 然而,这些标记物对于区分APA与良性腺瘤多或子宫内膜腺瘤是没有用处的.
科学领域:
- 妇科病理学 妇科病理学
- 手术病理学手术病理学
- 免疫组织化学 免疫组织化学
背景情况:
- 非典型多腺瘤 (APA) 是一种罕见的具有低恶性潜力的子宫病变.
- 在活检上区分APA与良性和恶性模仿是诊断上具有挑战性的.
- p16和SATB2表达是区分APA和肌肉侵入性子宫内膜癌的潜在生物标志物.
研究的目的:
- 评估p16和SATB2免疫组织化学在区分APA与良性腺瘤多和子宫内膜腺瘤的有用性.
- 评估p16和SATB2在区分APA与肌肉侵入性子宫内膜癌的诊断性能.
主要方法:
- 对10种不典型的多重性腺瘤 (APA) 的回顾性分析.
- 在APA中对p16和SATB2进行免疫组织化学染色,7种腺瘤多,11种子宫内膜腺瘤和10种肌肉侵入性子宫内膜癌.
- 评估p16和SATB2.2.的结构表达模式.
主要成果:
- APAs,腺瘤多和子宫内膜腺瘤显示了可变的p16和SATB2 stromal表达.
- 肌肉侵入性子宫内膜腺癌主要表现为负或弱,焦点p16和SATB2表达 (90%).
- p16和SATB2表达模式无法可靠地将APA与腺瘤多或子宫内腺瘤区分开来.
结论:
- p16和SATB2免疫组织化学在区分非典型的多腺瘤和肌肉侵袭性子宫内膜癌方面是有价值的.
- 这些标记在区分非典型的多腺瘤与良性腺瘤多和子宫内膜腺瘤方面缺乏实用性.
- 可能需要进一步调查,以确定可靠的标记,以诊断与良性模仿者相关的APA诊断.
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