对防晒产品中颗粒物和可溶性成分的细胞反应的区分
1School of Energy and Environment and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China; Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China.
Journal of hazardous materials
|June 4, 2024
概括
防晒的可溶性成分转化为有毒代谢物,导致整体细胞毒性. 颗粒物,如氧化 (ZnO),引起亚细胞损伤,而微塑料改变可溶性分量的行为.
科学领域:
- 环境毒理学环境毒理学
- 细胞生物学 细胞生物学
- 皮肤病学 皮肤病学
背景情况:
- 越来越多的人意识到防晒的风险,需要识别有毒成分.
- 防晒的毒性是复杂的,涉及各种成分之间的相互作用.
- 了解细胞对防晒混合物的反应对于风险评估至关重要.
研究的目的:
- 为了研究颗粒物和可溶性防晒分量的差异性毒性.
- 阐明生物转化在防晒引起的细胞毒性的作用.
- 识别可预测防晒暴露和毒性的细胞生物标志物.
主要方法:
- 将三种不同的防晒应用于HaCaT细胞.
- 对颗粒物和可溶性防晒分量的分析.
- 使用多线性回归分析对15种细胞生物标志物的评估.
主要成果:
- 内化溶解分数,特别是它们的生物转化代谢物,是整体细胞毒性的主要驱动因素.
- 塑料微球影响了可溶性分量的内部化和局部化.
- 生物可转化颗粒物 (例如,ZnO) 诱导的亚细胞毒性比生物惰性颗粒物 (例如,微塑料) 大.
- lysosomal 和线粒体生物标志物预测了防晒的存在.
结论:
- 防晒的毒性是可溶性和颗粒物成分之间的复杂相互作用.
- 溶解分量的生物转化对细胞毒性有显著的贡献.
- 颗粒物在亚细胞水平上产生毒性,生物可变性是关键因素.
- 特定的细胞生物标志物可以表明防晒暴露和潜在的毒性.
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