印度安福特素B脱氧酸治疗卡拉阿扎尔后皮肤莱什曼病的治疗方法
Shyam Sundar1,2, Jaya Chakravarty1, Jitendra Singh1
1Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
概括
对卡拉阿扎尔后皮肤雷什曼病 (PKDL) 进行较短的安福特素B (AmB) 治疗是非常有效的. 这种30次输液方案为流行地区的PKDL管理提供了一个有希望的替代方案.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 卡拉阿扎尔后皮肤雷什曼病 (PKDL) 在印度很普遍,目前的治疗方法如口服米尔特福辛具有显著的缺点,包括眼部毒性.
- 之前的治疗方法,如固醇和安二乙酸 (AmB) 与频繁的不良事件,高成本和长时间的治疗时间有关.
- 对PKDL进行更有效,更安全,更短的治疗方案的需求至关重要.
研究的目的:
- 为了评估安福特乙 (AmB) 缩短疗程治疗卡拉阿扎尔后皮肤雷什曼病 (PKDL) 的疗效和安全性.
- 分析治疗结果,包括不良事件和长期治愈率,在接受修改的AMB治疗方案的PKDL患者中.
主要方法:
- 一项回顾性研究审查了102名PKDL患者的医院记录,这些患者在60天内接受了30次AmB交替注射.
- 患者已经确认了寄生虫病的诊断,并对不良事件,治疗结束的寄生虫病状况和12个月的随访结果进行了评估.
主要成果:
- 90.2%的患者在缩短AMB治疗后出现改善.
- 87.3%的患者在12个月的随访期内实现了最终治愈.
- 2.9%的患者因不良反应而停止治疗;发生了一例与AmB无关的死亡.
结论:
- 一个30输液方案的安福特乙 (AmB) 是高度有效和一个可行的选择治疗后卡拉阿扎尔皮肤雷什曼病 (PKDL).
- 这种较短的AMB疗程提供了一个潜在的更安全,更易于管理的治疗替代方案,直到获得更优质的治疗方案.
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