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3D打印分散性埃法维伦兹片:在儿童中进行鼻胃施用的一种策略
Nadine Lysyk Funk1, Patricija Januskaite2, Ruy Carlos Ruver Beck3
1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
研究人员使用肠道养管 (EFT) 为艾滋病毒感染儿童开发了3D打印的分散性埃法维伦兹 (EFZ) 打印纸. 这种创新方法解决了为需要营养支持的儿科艾滋病毒患者提供药物的挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 3D打印应用 3D打印应用
- 儿童艾滋病毒治疗方法
背景情况:
- 肠道养管 (EFT) 对于艾滋病毒感染儿童的营养支持和药物输送至关重要.
- 对EFT的挑战包括非标签药物使用,不准确的剂量和管道堵塞.
- 需要改善使用EFT的儿科艾滋病毒患者的药物输送系统.
研究的目的:
- 开发和描述使用选择性激光烧结 (SLS) 3D打印的分散性 efavirenz (EFZ) 打印纸.
- 评估通过EFT给儿科艾滋病毒患者的印制小册子.
- 探索新的药物输送策略,以改善这一群体的药物管理.
主要方法:
- 选择性激光烧结 (SLS) 3D打印被用来创建EFZ打印.
- 使用水溶性聚合物 (Parteck® MXP和Kollidon® VA64) 来制造印刷品.
- 印刷品的特点是药物含量,无形化和分解时间.
主要成果:
- 使用SLS 3D打印成功制造了具有高药物含量 (20-40%w/w) 和无形化的多孔EFZ打印件.
- 用Parteck® MXP和Kollidon® VA64 (500mg和1000mg) 配制的打印纸显示在230秒内在水中分解.
- K1000印花板的部分分解表明了潜在的聚合物和问题.
结论:
- SLS 3D 打印为使用 EFT 的儿科艾滋病毒患者生产可分散 EFZ 打印单提供了一种可行的方法.
- 水友性聚合物可以在SLS 3D打印中有效地用于此应用.
- 对快速分解的聚合物和助剂进行进一步的研究是有必要的,以优化SLS 3D打印剂型以进行EFT.
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