蛋白质发生及其在过敏中的作用
1Safety and Environmental Assurance Centre, Unilever, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, U.K.
Chemical research in toxicology
|June 4, 2024
概括
电友化学物质可以改变人体蛋白质,导致SJS/TEN等过敏反应. 这篇评论探讨了触角化学,免疫反应和影响反应发展的因素.
科学领域:
- 化学生物学是化学生物学.
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 电友化学物质在日常生活中无处不在,包括药物,化品和环境暴露.
- 这些化学物质对蛋白质的共价修饰 (化) 是一个常见的细胞事件.
- 发生可以产生抗原物种,启动过敏反应.
研究的目的:
- 复习了化反应和新抗原形成的化学反应.
- 探索免疫系统的激活和由电友化学物质触发的细胞防御机制.
- 讨论影响过敏发展的因素和潜在的治疗应用.
主要方法:
- 概述了参与蛋白质合的化学反应.
- 对免疫系统激活途径的分析.
- 对电友化学物质暴露的细胞反应的检查.
主要成果:
- 催化,电友化学物质对蛋白质的共价变化,是过敏反应的分子启动事件.
- 简单和复杂的合反应,包括涉及细胞解毒的反应,都可能导致新抗原的形成.
- 电友化学物质也可以激活防御机制,具有各种细胞后果.
结论:
- 了解 haptenation 化学对于解释过敏反应至关重要.
- 调节触觉和免疫反应的因素决定了过敏症的发展.
- 发生特异性为设计有针对性的共价抑制剂用于治疗提供了潜力.
相关概念视频
Antigens Involved in Adaptive Immunity
485
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
485
Allergic Reactions
27.3K
Overview
27.3K
Hypersensitivities
601
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
601
Cross-reactivity
31.0K
Overview
31.0K
Antibody Structure
60.0K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.0K
Amino acids
88.7K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible...
88.7K


