使用F NMR从光-CORM量化CO释放:对光诱导的CO输送的调查
Upendar Reddy Gandra1, Jingjing Liu2, Jörg Axthelm2
1Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743, Jena, Germany; Department of Chemistry, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, United Arab Emirates.
Analytica chimica acta
|June 4, 2024
概括
量化治疗性一氧化碳 (CO) 是一个挑战. 一种新的光CORM (CORM-FBS) 和19F核磁共振方法精确测量CO释放,有助于治疗开发.
科学领域:
- 生物化学 生物化学
- 化学生物学 化学生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 一氧化碳 (CO) 是一种具有治疗潜力的内源信号分子.
- 准确的二氧化碳量化对于安全有效的治疗应用至关重要.
- 现有的方法,如肌红蛋白 (Mb) 测定,面临着新型CO释放分子 (CORM) 的挑战.
研究的目的:
- 开发一种新的,精确的方法来量化CORM释放的一氧化碳.
- 引入一种化光CORM (CORM-FBS) 用于光诱导的CO释放.
- 使用19F核磁共振光谱来监测和量化CO释放.
主要方法:
- 一种新的化光电CORM (CORM-FBS) 的合成和特征.
- 从CORM-FBS中释放的二氧化碳.
- 使用19FNMR光谱学对CO释放的定量评估.
主要成果:
- 从CORM-FBS中证明了成功的光诱导CO释放.
- 19F核磁共振光谱精确监测和量化了CO释放.
- 19F核磁共振方法对具有复杂分子结构的CORM有效.
结论:
- 19F核磁共振光谱提供了一种可靠和精确的方法来量化来自CORM的CO释放.
- 这种技术有助于开发涉及CO的新型治疗策略.
- 开发的方法在药物代谢和反应监测方面具有广泛的应用.
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