大脑网络拓及其对成年质瘤幸存者的认知影响
Laurien De Roeck1,2, Jeroen Blommaert3,4, Patrick Dupont4,5
1Department of Radiotherapy and Oncology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. Laurien.deroeck@uzleuven.be.
Scientific reports
|June 4, 2024
概括
大脑瘤幸存者显示大脑网络枢纽发生变化,特定的枢纽分类与注意力和智商有关. 这些发现可能有助于预测质瘤患者的认知结果.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 图形理论 图形理论
背景情况:
- 大脑瘤及其治疗方法可以破坏结构性大脑网络拓.
- 了解这些干扰对于评估幸存者的认知缺陷至关重要.
研究的目的:
- 研究结构性全脑和节点网络指标与质瘤幸存者的认知功能之间的关联.
- 为了确定质瘤幸存者和健康对照者之间大脑网络拓学的差异.
主要方法:
- 用扩散权重的MRI和全脑通道图来创建权重的大脑图形.
- 计算了节点和全脑图表指标,根据中心性指标确定了枢纽.
- 对50名质瘤幸存者和50名对照者进行认知评估,分数根据年龄和教育程度进行了校正.
主要成果:
- 与对照人群相比,瘤幸存者显示双边门枢纽显著减少.
- 枢纽分类性与幸存者的注意力和代理智商正相关.
- 全脑图表测量 (集群系数,全球/本地效率) 与代理智商相关.
结论:
- 瘤幸存者表现出大脑网络枢纽的潜在重组.
- 枢纽分类性与注意力和智商等认知功能有显著的关联.
- 这些网络变化及其认知关联对于理解和管理质瘤幸存者的长期结果很重要.
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