使用植物类化合物贝巴胺的培养方法通过调节细胞代谢来增强CAR-T细胞的疗效

Shin-Ichiro Takayanagi1,2,3, Sayaka Chuganji4,5, Masahiro Tanaka5

  • 1Kirin Central Research Institute, Kirin Holdings Company, Ltd., 26-1, Muraoka-Higashi 2, Fujisawa, Kanagawa, 251-8555, Japan. shinichiro.takayanagi.ky@kyowakirin.com.

PubMed
概括

柏巴胺 (BBM) 通过促进记忆T细胞表型,增强了仿真抗原受体 (CAR) -T细胞疗法. 这种天然化合物在白血病模型中改善了CAR-T细胞的持久性和抗瘤功效.

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