肥胖和减肥中的循环和中央内分泌系统
Nele Mattelaer1,2,3, Bart Van der Schueren1,4, Lukas Van Oudenhove2,3
1Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
International journal of obesity (2005)
|June 4, 2024
概括
减肥策略对内分泌大麻素系统 (ECS) 有影响,内分泌大麻素系统是食欲的关键调节器. 研究表明,在肥胖症和减肥干预后,循环内分泌素如AEA和2-AG的结果各不相同.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠-大脑轴对于调节食物摄入量和体重至关重要.
- 内分泌大麻素系统 (ECS) 显著影响食欲和体重管理.
- 关于减肥干预措施如何影响ECS的证据有限.
研究的目的:
- 审查现有的关于腹手术和人类其他减肥策略后中央和循环内分泌素水平变化的文献.
- 找出了解ECS在肥胖治疗中的作用的研究差距.
主要方法:
- 在PubMed,Embase和Web of Science数据库中的系统文献搜索.
- 包括56项人类研究,调查内分泌大麻素水平和体重管理.
- 对循环内分泌素水平 (2-AG,AEA) 和大脑大麻素受体1 (CB1) 的可用性进行分析.
主要成果:
- 循环中的2-阿拉基多诺伊尔甘油 (2-AG) 水平与肥胖的BMI没有明显的差异或相关性.
- 循环中的阿拉基多乙醇胺 (AEA) 水平经常增加或与BMI正相关.
- 在有限的研究中,大脑CB1受体的可用性与BMI有负相关性;减肥手术的结果是矛盾的.
结论:
- 目前的证据并没有明确支持肥胖症中循环内分泌素的上调.
- 研究群体的变化和混因素导致了相互矛盾的结果.
- 需要进一步研究手术和药理学诱导的减肥对ECS的影响.
相关概念视频
Regulation of Food Intake
220
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
220
Obesity
453
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
453
An Overview of the Endocrine System
8.2K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
The endocrine system collaborates...
8.2K
Hormonal Regulation
43.4K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.4K
The Endocrine System
255
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
255
Opioid Receptors: Overview
729
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
729


