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设想如何推进MASH领域的发展

Alina M Allen¹, Zobair M Younossi^2,3, Anna Mae Diehl⁴

¹Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Nature reviews. Gastroenterology & hepatology

|June 4, 2024

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与代谢功能障碍相关的脂肪性肝炎 (MASH) 需要持续的研究和政策行动. 解决这些条件至关重要,以减少到2030年它们的重大人力和经济负担.

科学领域:

肝病学和代谢疾病研究.
公共卫生和非传染性疾病的政策倡议.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
尽管取得了进展,但MASLD仍然是晚期肝病和肝癌的主要驱动因素.
最近的命名变化反映了对MASLD代谢基础的更深入的理解.

研究的目的:

将MASLD的命名结构转变置于背景,并概述未来进步的策略.
为患者护理,研究和解决MASLD/MASH.MASH中的健康差异提出优化建议.
详细说明新MASH治疗药物的监管途径,并加强卫生系统的准备.

主要方法:

这种观点综合了当前的科学理解和临床观察.
它审查了MASLD/MASH药物开发和监管途径的进展.
该方法涉及确定未来研究和政策干预的关键领域.

主要成果:

首个针对MASH的药物获得批准,标志着一个重要的里程碑.
自1980年以来,在了解和管理MASLD方面取得了实质性的进展.
加速进步的关键考虑因素包括多学科的护理,研究和政策.

结论:

需要采取协调一致的行动来应对MASLD和MASH对公共健康的威胁.
提高教育,意识和卫生系统的准备是至关重要的.
实现与其他非传染性疾病的平等性,需要政策制定者参与到2030年之前减少MASLD/MASH的负担.

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