脊椎体结合中的生长调节反应主要取决于形脊椎体生长的幅度
Craig R Louer1, Vidyadhar V Upasani2,3, Jennifer K Hurry4
1Department of Orthopedic Surgery, Vanderbilt University Medical Center, 2200 Childrens Way, Suite 4202, Nashville, TN, 37212, USA. Craig.louer@vumc.org.
Spine deformity
|June 4, 2024
概括
脊椎体绑定 (VBT) 在异常学脊椎病的成功取决于生长调制 (GM). 较强的GM与形脊椎生长和脊柱延长相关,而较差的GM可能表明带问题.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 整形外科 整形外科 整形外科
- 生物机械工程 生物机械工程
背景情况:
- 脊椎体绑定 (VBT) 用于治疗特异性脊椎病.
- 临床结果各不相同,部分原因是对生长调节 (GM) 的不完全理解.
- 在VBT期间表征形态变化对于改善患者的治疗结果至关重要.
研究的目的:
- 在VBT后的前两年,在生长调制 (GM) 期间表征脊椎和圆盘形态变化.
- 为了详细分析,利用现有最大的患者样本进行3D脊柱重建.
- 了解影响VBT临床结果变异性的因素.
主要方法:
- 一个多中心注册中心确定了接受VBT的异常学脊椎病患者,并对其进行了2年的随访.
- 校准的双平面X射线用于3D重建和精确的形态测量.
- 增长调节 (GM) 被定义为从手术后到2年的仪器化冠状元角变化.
主要成果:
- 分析了50名患者 (平均年龄为12.5岁).
- 基因转基因与形脊椎高度增长 (r=0.57,p<0.001) 和3D脊椎长度增长 (r=0.36,p=0.008) 呈正相关性.
- 高基因转基因响应者与低响应者相比 (2.3比0.7毫米,p=0.039) 显示出明显更大的形脊椎生长.
结论:
- 成功的VBT促进了不对称的脊椎体生长,使持续的冠状角纠正 (GM) 成为可能.
- 强烈的转基因反应与形脊椎体高度增长和整体仪器脊柱增长有关.
- 糟糕的转基因反应可能与凸圆盘高度的增加有关,这可能表明绳索断裂.
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