炎症轨迹与子arachnoid 出血死亡率的关联
Mingjiang Sun1, Xin Tong1, Xiaopeng Xue1
1Department of Neurosurgery, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Neurosurgical review
|June 4, 2024
概括
在甲状腺下出血 (SAH) 患者中,白细胞 (WBC) 轨迹升高,即使下降,也与更高的住院死亡率有关. 这一发现强调了随着时间的推移跟踪WBC模式的预后价值.
科学领域:
- 神经学 神经学
- 炎症生物学 炎症生物学
- 医学统计 医学统计
背景情况:
- 白细胞 (WBC) 计数是炎症的标志物.
- 在下大脑下出血 (SAH) 患者的入院时,增加的白细胞计数与预后不佳相关.
- 在SAH住院期间纵向WBC模式的意义尚不清楚.
研究的目的:
- 为了研究不同白细胞 (WBC) 轨迹模式和脑下关节下出血 (SAH) 患者的住院死亡率之间的关联.
主要方法:
- 506名SAH患者 (2012-2020年) 的回顾性队列分析.
- 基于组的轨迹建模 (GBTM) 来识别前4天的WBC模式.
- 稳定逆概率治疗权重 (sIPTW) 和Cox比例危险模型用于关联分析.
主要成果:
- 在SAH患者中确定了两个不同的纵向WBC轨迹.
- 一个升高的WBC轨迹,以最初高,然后下降的数量为特征,与增加的住院死亡率有关 (HR2.472,P=0.018加权后).
结论:
- 在SAH中,WBC轨迹分析可以确定临床相关的患者组.
- 最初升高,随后降低白细胞计数的模式可能表明SAH后住院死亡风险更高.
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