饮食中的酸负荷和卵巢储备减少的风险:一个病例对照研究
Rahele Ziaei1, Abed Ghavami1, Hatav Ghasemi-Tehrani2
1Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Reproductive biology and endocrinology : RB&E
|June 4, 2024
概括
含酸量高的饮食可能会对卵巢储备产生负面影响. 高食酸负载 (DAL) 与减少卵巢储备 (DOR) 的风险增加有关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 关于饮食中的酸负荷与卵巢储备减少 (DOR) 之间的联系的证据有限.
- 调查饮食酸负荷 (DAL) 和卵巢储备标志物之间的关系至关重要.
研究的目的:
- 探索饮食酸负荷 (DAL) 与卵巢储备减少 (DOR) 风险之间的关联.
- 检查DAL,潜在酸负荷 (PRAL),内源性净酸产量 (NEAP) 和卵巢储备标志物之间的关系.
主要方法:
- 一项涉及370名女性的病例控制研究 (120名DOR,250名对照) 根据年龄和BMI进行了匹配.
- 通过80项半定量食品频率问卷 (FFQ) 评估饮食摄入量.
- 计算DAL分数 (PRAL,NEAP);使用后勤回归来确定DOR在四分位数中的赔率比率 (OR).
主要成果:
- 在患有DOR的女性中,增加的PRAL和NEAP得分与血清抗穆勒尔激素 (AMH) 降低相关.
- 较高的PRAL得分与腹毛囊数量 (AFC) 的显著下降有关.
- 在PRAL得分的上四分之一中,DOR的赔率比率增加 (OR:1.26).
结论:
- 具有高酸形成潜力的饮食可能会对卵巢储备产生不利影响.
- 饮食酸负荷 (DAL) 增加可能会增加卵巢储备减少 (DOR) 的风险.
- 需要进一步的前性研究和临床试验来证实DAL与卵巢储备的关联.
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