胃肠道胰腺神经内分泌瘤:当前的发展,挑战和临床前景
Xian-Bin Zhang1, Yi-Bao Fan1,2, Rui Jing3
1Department of General SurgeryInstitute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Military Medical Research
|June 4, 2024
概括
胃肠道胰腺神经内分泌瘤 (GEP-NENs) 越来越常见和攻击性. 本综述强调了最近在诊断和治疗这些瘤方面的进展和挑战,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 神经内分泌瘤 (NENs) 是源自神经内分泌细胞的多种瘤.
- 胃肠道胰腺神经内分泌瘤 (GEP-NENs) 是最常见的NEN亚型.
- 最近的数据显示,在过去30年中,GEP-NEN的流行和发病率显著增加,挑战了他们作为罕见和缓慢增长的历史观点.
研究的目的:
- 审查目前关于GEP-NENs的知识,重点关注流行病学,临床特征,病理学和分子生物学.
- 总结最近在GEP-NENs的诊断和治疗方面的进展.
- 确定导致GEP-NEN患者诊断和治疗延迟的因素.
主要方法:
- 关于GEP-NENs的流行病学,临床,病理学,分子,诊断和治疗数据的综合文献综述.
- 分析最近在理解GEP-NENs方面的进展和局限性.
- 确定影响延迟诊断和治疗的关键因素.
主要成果:
- 在全球范围内,GEP-NEN的流行和发病率都在增加.
- 证据表明,比以前假设的更具侵略性的生物行为.
- 需要改善诊断和管理策略至关重要.
结论:
- 由于其日益增多的发病率和攻击性,GEP-NEN 代表着日益增长的临床挑战.
- 解决诊断和治疗延迟对于改善患者的治疗结果至关重要.
- 进一步的研究是必不可少的,以提高对GEP-NEN的理解和管理.
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