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肠道微生物群与慢性病的关联:对营养和炎症参数的洞察
Vladimir Lazarevic1, Daniel Teta2, Menno Pruijm3
1Genomic Research Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Frontiers in microbiology
|June 5, 2024
概括
血液透析患者表现出肠道微生物群的改变和炎症增加,影响食欲和营养状况. 这些肠道屏障变化与病进展和整体健康有关.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
背景情况:
- 肠道屏障,包括肠道微生物群,对于慢性病 (CKD) 的进展和营养状况至关重要.
- 了解CKD患者的肠道屏障变化对于管理疾病进展和改善患者的治疗结果至关重要.
研究的目的:
- 为了研究血液透析 (HD) 患者,非HD (NHD) 慢性结核病患者和健康志愿者的肠道屏障变化.
- 探索肠道微生物组成,全身炎症,食欲调解剂和CKD患者的营养状况之间的关系.
主要方法:
- 一项涉及22名HD患者,11名NHD患者和11名健康志愿者的横截面研究.
- 评估了便微生物群组成 (16S rRNA基因测序),便IgA,肠道透性标记物,血清细胞因子,食欲调解物,营养状况,体力活动和生活质量.
主要成果:
- 与健康志愿者相比,HD患者表现出明显的便微生物群变化,特定细菌种群的变化.
- 患HD患者的炎症标志物 (CRP,IL-6,TNF-α),葡萄糖样-2,以及厌食性标志物 (莱普,YY) 的升高. 在NHD患者中,CRP和YY的增加.
- 便微生物群的组成与各种人体测量,身体组成和生物化学标记相关,包括血白蛋白和TNF-α.
结论:
- 与健康个体相比,HD患者表现出改变的便微生物群,增加的全身炎症和改变的食欲媒介水平.
- 在CKD患者中观察到的异质性表明生活方式和并发症对肠道屏障完整性的影响.
- 需要在更大的队列中进行进一步的研究,以阐明肠道微生物群,生理标志物和功能之间的复杂相互作用.
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