维生素D与儿童急性呼吸道感染
Esther Ngozi Umeadi1,2, Sylvia Tochukwu Echendu1,2, Chinyelu Uchenna Ufoaroh3,4
1Department of Paediatrics, Nnamdi Azikiwe University, Awka Nigeria.
概括
低维生素D水平在尼日利亚五岁以下的儿童中很常见,与急性下呼吸道感染 (ALRI) 相关,而不是急性上呼吸道感染 (AURI).
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 急性呼吸道感染 (ARI) 是5岁以下儿童的重大健康问题.
- 维生素D缺乏在全球普遍存在,可能会影响免疫功能.
- 这项研究调查了尼日利亚儿童血清维生素D和ARI之间的关系.
研究的目的:
- 评估血清维生素D水平与5岁以下儿童ARI发病率之间的关联.
- 为了比较ARI和没有ARI的儿童之间的维生素D水平.
- 要确定急性上呼吸道感染 (AURI) 和急性下呼吸道感染 (ALRI) 之间是否存在维生素D水平的差异.
主要方法:
- 2017年,尼日利亚Nnamdi Azikiwe大学教学医院 (NAUTH) 进行了一项病例控制研究.
- 250名患有ARI (AURI和ALRI) 的儿童和250名没有ARI的年龄和性别匹配的对照儿童被录取.
- 收集了血清25(OH) D水平和社会人口统计数据,并在各组之间进行了比较.
主要成果:
- 与对照组 (57.0±23.9 ng/ml) 相比,患有ARI (52.2±25.6 ng/ml) 的儿童的血清中平均25(OH) D水平较低 (p=0.03).
- 患有ALRI的儿童的血清25(OH) D水平 (39.8±23.8 ng/ml) 比患有AURI (56.0±24.9 ng/ml) 的儿童要低得多 (p<0.001).
- 低血清25(OH) D水平与ALRI的严重程度显著相关 (p=0.002).
结论:
- 在这个尼日利亚队伍中,五岁以下儿童的血清维生素D水平较低.
- 低维生素D水平与ALRI比AURI更强烈地相关.
- 维生素D的状况可能在幼儿严重呼吸道感染的发病过程中发挥作用.
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