母亲产后抑郁症状与婴儿神经发育和肠道微生物群的关联
Lepeng Zhou1, Linghong Tang1, Chuhui Zhou1,2
1School of Nursing, Southern Medical University, Guangzhou, Guangdong, China.
Frontiers in psychiatry
|June 5, 2024
概括
母亲产后抑郁症 (PPD) 与婴儿肠道微生物组的变化和较低的神经发育有关. 特定的肠道代谢物调解母亲PPD对婴儿解决问题的能力的影响.
科学领域:
- 围产期心理健康问题
- 婴儿神经发育 婴儿神经发育
- 肠道微生物组研究研究
背景情况:
- 母亲产后抑郁症 (PPD) 显著影响婴儿发育,但连接PPD,肠道微生物群和神经发育的机制尚不清楚.
- 关于母亲PPD,婴儿肠道微生物群组成和早期神经发育结果之间的相互作用的研究有限.
研究的目的:
- 为了研究母亲PPD症状与婴儿6个月的肠道微生物组,代谢组和神经发育之间的关联.
- 确定肠道代谢产物的潜在中介作用在母亲的PPD和婴儿神经发育之间的关系.
主要方法:
- 通过爱丁堡产后抑郁症量表 (EPDS) 评估母亲的PPD症状.
- 使用16S rRNA测序分析婴儿肠道微生物群;通过LC-MS分析代谢组.
- 在6个月时使用年龄和阶段问卷 (ASQ-3) 评估婴儿神经发育.
- 同时发生的网络和调解分析用于确定相关性和因果关系途径.
主要成果:
- 患有PPD症状的母亲的婴儿在6个月时显示神经发育得分降低.
- 婴儿肠道微生物组合的显著变化,包括增加的α多样性和特定细菌丰度的变化 (例如,枯竭的Bifidobacterium).
- 肠道代谢物的变化,特别是N-乙-L-酸和L-酸水平的降低,与氨酸,酸和谷氨酸通路有关.
- N-乙-L-酸和L-酸调解了母亲PPD和婴儿解决问题的技能之间的关联.
结论:
- 孕产妇的PPD与婴儿的肠道微生物组和代谢组特征有关,影响神经发育.
- 肠道代谢物,特别是N-乙-L-酸和L-酸,可能在母亲的PPD如何影响婴儿的认知能力方面发挥中介作用.
- 研究结果表明,在暴露于母亲PPD的婴儿中,可能是早期干预的潜在目标.
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