关于指甲单元状细胞癌的最新情况:人类乳头瘤病毒相关的疾病
Eric R Bray1, Antonella Tosti1, Brian W Morrison1
1Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Skin appendage disorders
|June 5, 2024
概括
指甲单元的状细胞癌 (SCC) 与人类乳头瘤病毒 (HPV) 有关. 接种HPV疫苗对治疗和预防这些常见的手指恶性瘤有希望.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 病毒学 病毒学
背景情况:
- 状细胞癌 (SCC) 和SCC in situ (恩病) 是最常见的指甲单位恶性瘤.
- 这些情况主要影响50岁以上的男性,他们偏爱手指.
- 高风险的人类乳头瘤病毒 (HPV) 感染是指甲单元SCC.病变发生的一个重要因素.
研究的目的:
- 审查HPV在指甲单元SCC的发展中的作用.
- 检查生殖指纹HPV传播和HPV相关指甲SCC的临床特征.
- 讨论当前的治疗策略和HPV疫苗接种的潜力.
主要方法:
- 文献综述和当前研究的综合.
- 对流行病学数据和病因因素的分析.
- 评估治疗选择和预防策略.
主要成果:
- 指甲单位SCC与HPV感染有很强的关联.
- 生殖器数字传播是指甲SCC中HPV获取的相关途径.
- HPV 疫苗接种正在成为一种潜在的治疗和预防措施.
结论:
- 指甲单位SCC应该被认为是HPV驱动的恶性瘤.
- 接种HPV疫苗为管理指甲单元SCC提供了潜在的非手术方法.
- 需要进一步的研究,以优化针对指甲SCC的HPV疫苗接种策略.
相关概念视频
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K


