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调控性T细胞和T辅助细胞17细胞失衡在患有不明原因不孕症的患者中

Liang Lu¹, Yan Lu², Longyi Zhang²

¹Department of Reproductive Center, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, People's Republic of China.

International journal of women's health

|June 5, 2024

概括

Th17/Treg比率是一个有前途的诊断生物标志物,用于无法解释的不孕症 (UI),由于调节性T细胞 (Treg) 和辅助性T细胞17 (Th17) 的失衡. 这一比率在UI患者中显示出良好的诊断性能.

科学领域:

免疫学免疫学免疫学
生殖医学生殖医学
不孕症研究不孕症研究

背景情况:

女性不孕症,特别是无法解释的不孕症 (UI),是全球重要的健康问题.
免疫细胞,特别是调控性T细胞 (Treg) 和辅助性T细胞17 (Th17) 在UI病原发生中的作用需要进一步阐明.

研究的目的:

为了研究Treg和Th17细胞之间的关系,在外周血液的妇女与UI.
探索Treg和Th17细胞作为UI的诊断生物标志物的潜力.
要确定Treg和Th17细胞分布在初级和二级UI之间是否有差异.

主要方法:

对37名UI患者和26名对照进行了标准生育评估.
使用流细胞计量来量化Treg和Th17细胞频率.
接收器操作特征 (ROC) 曲线分析评估了诊断性能,曲线下面面积 (AUC) > 0.800表明性能良好.

主要成果:

患有UI的患者表现出Treg细胞的显著减少和Th17细胞的显著增加,导致Th17/Treg比率升高.
Th17/Treg比率显示了UI的强大诊断性能,其AUC为0.813.
在Treg和Th17细胞分布或Th17/Treg比率在初级和二级UI病例之间没有观察到显著差异.

结论:

在Treg和Th17细胞分布中的不平衡,反映在Th17/Treg比率中,与无法解释的不孕症有关.
Th17/Treg比率显示出作为UI的有价值的诊断生物标志物的潜力.
该研究没有发现Treg和Th17细胞分布在初级和二级UI之间存在显著差异.

关键词:

辅助T细胞17细胞生物标志物生物标志物女性不孕症女性不孕症免疫学免疫学免疫学监管性T细胞监管性T细胞无法解释的不孕不育.

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