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相关实验视频

Updated: Jun 24, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

在实验室中设计一个视网膜体内神经模型.

Giulia Amos¹, Stephan J Ihle¹, Blandine F Clément¹

¹Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland.

Frontiers in neuroscience

|June 5, 2024

概括

这项研究使用微流体通道开发了视网膜原蛋白质通路的体外模型. 较短的通道 (0.5-2毫米) 保持了网络完整性,而较长的通道则损害了信号传输.

关键词:

工程神经网络的工程神经网络.微电极阵列是一个微电极阵列.网红原素化途径的发生.尖峰传播的传播单向传输是一种单向传输.

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Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Published on: October 15, 2017

相关实验视频

Last Updated: Jun 24, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches

Published on: June 21, 2022

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Published on: October 15, 2017

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
发展生物学发展生物学

背景情况:

视网基化路径对于视觉处理至关重要.
了解其在体外的发展有助于治疗策略.
现有的模型缺乏研究信号传输动态的复杂性.

研究的目的:

开发和验证一种新的"体外"微流体系统,用于研究视网膜生成路径.
研究道长度对神经网络形成和信号传播的影响.
评估电刺激参数对体目标反应的影响.

主要方法:

基于聚甲基 (PDMS) 的双腔系统与轴突引导通道被设计出来.
胚胎大鼠视网膜球体被培养,通过微流体通道 (高达6毫米) 通过乳头内 target.
用电刺激和功能成像来评估微电极阵列上的网络功能.

主要成果:

网络完整性 (形态和功能) 在较短的通道 (0.5-2毫米) 中显著更高.
较长的通道 (>4毫米) 显示尖端传播和传导保真度降低.
观察到乳头目标活性和持续的反应 (高达31 Hz的刺激).

结论:

频道长度极大地影响视网状体网络的形成和信号传输in vitro.
开发的平台可以对神经网络的发展和功能进行高通量分析.
该模型提供了对视觉通路发展和潜在治疗干预措施的见解.