皮原性脊椎骨髓炎患者的中期存活率和风险因素分析:对155例病例的回顾性研究
Melanie Schindler1, Nike Walter1, Jan Reinhard2
1Department of Trauma Surgery, University Hospital Regensburg, Regensburg, Germany.
Frontiers in surgery
|June 5, 2024
概括
发烧性脊椎骨质炎 (VO) 是一种严重的疾病,死亡率高. 充血性心力衰竭和脏疾病显著增加了VO患者的死亡风险,突出了早期风险因素评估和败血症管理的需要.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 临床流行病学临床流行病学
背景情况:
- 发烧性脊椎骨质炎 (VO) 带来了重大的临床挑战,与高发病率和死亡率有关.
- 了解VO患者的死亡率及其贡献风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查与发病性脊椎骨髓炎 (VO) 相关的死亡率.
- 为了确定潜在的风险因素,有助于在医院内死亡率的VO患者.
主要方法:
- 在2000年至2020年期间治疗的155名VO患者的回顾性分析.
- 利用ICD-10代码进行患者识别,分析住院死亡率,并发病症和确诊的病原体.
- 用Kaplan-Meier图表和几率比率 (OR) 来评估死亡概率和风险因素.
主要成果:
- 平均随访时间为87.8个月,总死亡率为34.1%,1年,2年,5年死亡率分别为17.2%,19.9%和28.3%.
- 充血性心力衰竭,病,残残症症状和败血症与较高的死亡率有显著的关联.
- 在56.1%的病例中确定了病原体,其中金黄色葡萄球菌是常见的. 病 (OR 1.85) 和充血性心力衰竭 (OR 1.52) 是显著的危险因素.
结论:
- 早期评估患者特异性风险因素对于管理VO和降低死亡率至关重要.
- 密切监测慢性器官疾病的VO患者和及时的败血症治疗是必不可少的.
- 优先考虑病原体识别和抗生素敏感性测试可以改善这种高风险人群的结果.
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