减少或停止胰岛素或硫氨基尿素,当启动一个类似于葡萄糖的-1激动剂
Emily Herron1, Joseph Cencetti1, James Matis1
1Wilkes-Barre Veterans Affairs Medical Center, Pennsylvania.
概括
在2型糖尿病的胰岛素或硫尿素治疗中添加类似葡萄糖类-1 (GLP-1) 激应剂往往会导致降低剂量或停止使用这些较旧的药物. 这一策略有助于预防低血糖症并有效控制体重.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 糖尿病管理 糖尿病管理
背景情况:
- 胰岛素和硫尿素通常会导致2型糖尿病患者的低血糖和体重增加.
- 葡萄糖类-1 (GLP-1) 激动剂在单一治疗中低血糖的发病率较低.
- 将GLP-1激动剂与胰岛素或硫尿素结合使用会增加低血糖的风险.
研究的目的:
- 评估是否需要降低剂量或停止使用胰岛素或硫尿素与GLP-1激动剂结合时.
- 评估GLP-1激动剂启动对血糖控制和体重的影响.
主要方法:
- 对136名患有2型糖尿病的胰岛素和/或硫尿素患者的回顾性图表审查,最初是用GLP-1激动剂开始的.
- 从2019年1月到2022年9月在药剂师领导的诊所收集的数据.
- 主要结局:在3,6和12个月后降低或停止胰岛素/硫基尿素剂量的患者百分比.
主要成果:
- 在12个月内,57.3%的患者降低了胰岛素剂量,14.6%的人停止了胰岛素.
- 29.6%的人减少了硫基尿素剂量,38.9%的人停止了服用.
- 接受胰岛素和硫氨酸尿素治疗的患者需要更密切的监测,因为停药率更高.
结论:
- 将GLP-1激动剂与胰岛素或硫尿素结合使用需要调整药物.
- 减少老药剂的剂量或停止使用可以通过预防低血糖症和帮助体重管理来改善患者的结果.
- 药剂师主导的干预措施对于优化2型糖尿病的联合治疗至关重要.
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