系统性硬化症泰国患者的肺功能;一个单一中心6年后期研究
Pattarin Pirompanich1, Ornnicha Sathitakorn2, Thitisak Sakulvorakitti2
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Thammasat University, Bangkok, Bangkok, 12120, Thailand.
F1000Research
|June 5, 2024
概括
限制性螺旋测量模式在泰国患有全身性硬化症 (SSc) 的患者中很常见. 然而,人口统计数据和抗Scl70状态在预测SSc.肺部参与方面具有有限的力量.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 内部医学 内部医学
背景情况:
- 系统性硬化症 (SSc) 与严重的肺部并发症有关,是导致死亡的主要原因.
- 肺部参与SSc影响内部器官功能和患者的存活率.
- 了解SSc中的肺功能 (PF) 特征对于患者管理至关重要.
研究的目的:
- 在泰国患有全身性硬化症 (SSc) 的患者中描述肺功能 (PF).
- 在SSc患者中调查PF,体重指数 (BMI) 和抗毒素酶 (anti-Scl70) 抗体状态之间的关联.
主要方法:
- 在2016-2021年期间在第三级护理医院诊断的SSc患者的回顾性分析.
- 包括128名接受肺功能检测的SSc患者.
- 收集的数据包括人口统计,BMI,抗Scl70状态和螺旋计结果 (FEV1,FVC,DLCO).
主要成果:
- 在128名SSc患者中,限制性螺旋测量模式 (RSP) 在78.8%的患者中普遍存在.
- 肺部对一氧化碳的扩散能力 (DLCO) 与强迫生命能力 (FVC) (r=0.50) 有中度的正相关性,与BMI有中度的负相关性 (r=-0.36).
- 在FVC和BMI之间没有发现显著的相关性,在RSP或没有RSP的患者之间也没有人口统计数据或反Scl70状态的统计差异.
结论:
- 限制性螺旋测量模式在泰国SSc患者中很常见.
- 目前的人口统计数据和抗Scl70状态对SSc.肺部参与的预测价值有限.
- 可能需要进一步的研究来确定SSc.肺部并发症的更可靠预测因素.
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