遗传预测的大型抑郁症因果性地增加了关节疾病的风险
Shiqian Wu1, Zhuo Chen1, Yawen Zhao1
1Department of Stomatology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Frontiers in genetics
|June 5, 2024
概括
根据孟德尔随机化 (MR) 分析,严重抑郁症显著增加了关节疾病 (TMD) 的风险. 这项研究没有发现双相情感障碍或精神分裂症与TMD之间的因果关系,突出显示了抑郁症.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 口腔和牙面部外科手术
背景情况:
- 观察性研究表明,精神疾病和关节疾病 (TMD) 之间存在共患.
- 常见的精神疾病和TMD之间的因果关系尚不清楚.
- 门德尔随机化 (MR) 用于调查潜在的因果关系.
研究的目的:
- 澄清主要抑郁症,双相情感障碍,精神分裂症和TMD之间的因果关系.
- 利用大规模的全基因组关联研究 (GWAS) 数据进行强大的遗传分析.
主要方法:
- 从精神病基因组学联盟获取了GWAS主要抑郁症,双相情感障碍和精神分裂症的总结数据.
- 获得的TMD总结数据来自Finn-Gen联盟 (211,023名受试者).
- 采用逆方差权衡 (IVW) 作为主要分析方法,并补充了五种灵敏度分析 (MR-Egger,最大概率,加权中位数,MR-RAPS,MR-PRESSO).
- 进行异质性和性测试,以确保结果的可靠性.
主要成果:
- 基因决定的大型抑郁症与通过IVW增加1.65倍的TMD风险 (95% CI = 1.10-2.47,p < 0.05) 相关.
- 敏感性分析始终支持大抑郁症和TMD之间的关联.
- 在双相情感障碍或精神分裂症和TMD之间没有发现显著的因果关系.
结论:
- 遗传证据支持大抑郁症和TMD之间存在因果关系.
- 双极性障碍和精神分裂症似乎与TMD没有因果关系.
- 对患有TMD的患者来说,临床评估抑郁状态很重要.
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