相关实验视频
Updated: Jun 24, 2025

10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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在患有高风险专利卵膜的老年患者中,在密码性中风后关闭器件或进行抗血栓治疗
Pil Hyung Lee1, Jung-Sun Kim2, Jae-Kwan Song1
1Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Journal of stroke
|June 5, 2024
概括
通过皮肤关闭 patent foramen ovale (PFO) 显著减少老年患者中风和TIA的复发. 关闭设备为这种高风险人群提供了一个有希望的干预措施.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 在年轻患者中, patent foramen ovale (PFO) 与中风有关.
- 在患有密码性中风的老年患者 (≥60岁) 中,PFO关闭的疗效尚未得到充分证实.
研究的目的:
- 评估皮肤穿PFO关闭在预防老年患者复发性缺血性中风或短暂性缺血性发作 (TIA) 的有效性.
主要方法:
- 对60岁以上的患有密码性中风和PFO的患者进行了 propensity-score匹配分析.
- 这项研究比较了PFO关闭加上医疗治疗与单独的医疗治疗.
- 亚组分析包括高风险PFO (心房隔膜动脉瘤或大分离) 的患者.
主要成果:
- 在整体匹配队列中,PFO关闭显著降低了缺血性中风或TIA的复合风险 (HR:0.45;P=0.012).
- 在高风险的PFO患者中,关闭显著降低了复合事件 (HR:0.40;P=0.006) 和缺血性中风 (HR:0.47;P=0.035) 的风险.
结论:
- 患有密码性中风和PFO的老年患者经历了高的复发事件率.
- 透皮PFO关闭可以显著降低这种人口中的缺血性中风和TIA的复发率.
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