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Updated: Aug 12, 2026

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
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通过吸入暴露于颗粒会在老鼠大脑中触发早期毒性标志物的表达

Léo Macé1, Chloé Brizais1, Florence Bachelot1

  • 1Institut de Radioprotection et de Sûreté Nucléaire, Pôle Santé Environnement, Service de recherche sur les effets biologiques et sanitaires des rayonnements ionisants, Avenue de la Division Leclerc, Fontenay aux Roses, France.

Inhalation toxicology
|June 5, 2024
PubMed
概括

吸入颗粒可能会损害大脑细胞,影响微质细胞和神经元,特别是在更高度时. 这项研究质疑的存在.

关键词:
吸入式吸入方式微质细胞中的微质细胞神经元遭受的痛苦是什么?神经毒性的作用.氧化应激是一种氧化应激.的是一种.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...