肠道微生物组和移植后的症状负担:概述和研究机会
Mark B Lockwood1, Choa Sung2, Suzanne A Alvernaz3
1Department of Biobehavioral Nursing Science, University of Illinois Chicago College of Nursing, Chicago, IL, USA.
Biological research for nursing
|June 5, 2024
概括
移植脏的患者往往有很高的症状负担影响生活质量. 肠道微生物群可以通过肠-大脑-微生物群轴影响这些症状,特别是在药物暴露后.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 接受脏移植的人经常经历持续的高症状负担,对生活质量产生负面影响,导致不坚持,排斥,移植损失和死亡率等不良结果.
- 肠道微生物组通过与免疫,内分泌和神经系统相互作用,在宿主恒常中发挥着至关重要的作用.
- 由于移植后的药物,肠道微生物组的变化可能会破坏其保护功能.
研究的目的:
- 审查当前对肠道微生物群对接受移植患者症状负担的影响的科学理解.
- 探索肠-大脑-微生物群轴作为一种潜在的症状调解机制.
- 确定该领域未来的研究方向.
主要方法:
- 对肠道微生物组,症状负担和移植现有研究的文献综述.
- 分析肠-大脑-微生物群轴在调解症状中的作用.
- 讨论免疫抑制剂,抗生素和抗病毒药物对肠道微生物群的影响.
主要成果:
- 高症状负担在移植后普遍存在,并与糟糕的结果有关.
- 肠道微生物群影响宿主系统,其破坏与各种慢性疾病有关.
- 移植后的药物显著改变肠道微生物群的组成和功能.
结论:
- 肠道微生物组是导致移植患者症状负担的潜在因素.
- 了解肠-大脑-微生物群轴为症状管理提供了治疗目标.
- 需要进一步的研究来阐明这些机制,并制定有针对性的干预措施.
相关概念视频
Tissue Transplantation
358
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
358
Irritable Bowel Syndrome I: Introduction
268
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
268
Cell-mediated Immune Responses
68.1K
Overview
68.1K
Assessment of the Gastrointestinal System I: Subjective Data
177
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
177


